Fosaprepitant dimeglumine ( MK 0517 )

产品货号. M13812 CAS No. 265121-04-8

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

拼团产品询价大包装询价加入购物车

产品名称

Fosaprepitant dimeglumine
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

Fosaprepitant dimeglumine(MK-0517) is a neurokinin-1 receptor antagonist for the prevention of chemotherapy-induced nausea and vomiting.
产品描述

Fosaprepitant dimeglumine(MK-0517) is a neurokinin-1 receptor antagonist for the prevention of chemotherapy-induced nausea and vomiting.
同义词

MK 0517
通路

GPCR/G Protein
靶点

Neurokinin Receptor
受体

NK1
研究领域

Neurological Disease
适应症

——

CAS Number

265121-04-8
分子量

1004.83
分子式

C37H56F7N6O16P
纯度

>98%(HPLC)
溶解度

Water: 135 mg/mL (134.35 mM); DMSO: 201 mg/mL (200.03 mM)
SMILES

C[C@H](C1=CC(=CC(=C1)C(F)(F)F)C(F)(F)F)O[C@@H]2[C@@H](N(CCO2)CC3=NC(=O)N(N3)P(=O)(O)O)C4=CC=C(C=C4)F.CNC[C@@H]([C@H]([C@@H]([C@@H](CO)O)O)O)O.CNC[C@@H]([C@H]([C@@H]([C@@H](CO)O)O)O)O
化学全称

——

1.Navari RM. Expert Opin Investig Drugs, 2007, 16(12), 1977-1985.

计算器

产品手册

关联产品

[Sar9,Met(O2)11]-Sub...

Sar9, Met (O2)11-Substance P is a neurokinin-1 receptor agonist. It is an analog of the naturally occurring human neuropeptide Substance P, which can be found throughout the body, including in the airways of humans and many other species.
Hemokinin 1 (mouse)

Hemokinin 1 (mouse) is a selective excitogen 1 receptor agonist with a Ki value of 0.175 nM for the human NK1 receptor and 560 nM for the human NK2 receptor.
Ibodutant

A potent and selective linear tachykinin NK2 receptor antagonist with pKb of 9.3; displays >1,000-fold selectivity over NK1 and NK3 (pKb<6).